Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V)‎, Bismuth (V)‎, and Tin (IV)‎ Complexes of Lapachol

المؤلفون المشاركون

Rocha, Marcele Neves
Frézard, Frédéric
da Silva, Meiriane Mariano
Nogueira, Paula Monalisa
de Oliveira, Ludmila Gonçalvez
Demicheli, Cynthia
Melo, Maria Norma
Soares, Rodrigo Pedro

المصدر

Bioinorganic Chemistry and Applications

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-05-25

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance.

Lapachol [2-hydroxy-3-(3′-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens.

In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides complexes with antimony (V), bismuth (V), and tin (IV) against L.

amazonensis.

All seven compounds exhibited antileishmanial activity, but most of the antimony (V) and bismuth (V) complexes were toxic against human HepG2 cells and murine macrophages.

The best IC50 values (0.17 ± 0.03 and 0.10 ± 0.11 μg/mL) were observed for Tin (IV) complexes (3) [(Lp)(Ph3Sn)] and (6) (Ph3SnCl2), respectively.

Their selective indexes (SIs) were 70.65 and 120.35 for HepG2 cells, respectively.

However, while analyzing murine macrophages, the SI decreased.

Those compounds were moderately toxic for HepG2 cells and toxic for murine macrophages, still underlying the need of chemical modification in this class of compounds.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Rocha, Marcele Neves& Nogueira, Paula Monalisa& Demicheli, Cynthia& de Oliveira, Ludmila Gonçalvez& da Silva, Meiriane Mariano& Frézard, Frédéric…[et al.]. 2013. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511717

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Rocha, Marcele Neves…[et al.]. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-511717

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Rocha, Marcele Neves& Nogueira, Paula Monalisa& Demicheli, Cynthia& de Oliveira, Ludmila Gonçalvez& da Silva, Meiriane Mariano& Frézard, Frédéric…[et al.]. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511717

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-511717