Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol
Joint Authors
Rocha, Marcele Neves
Frézard, Frédéric
da Silva, Meiriane Mariano
Nogueira, Paula Monalisa
de Oliveira, Ludmila Gonçalvez
Demicheli, Cynthia
Melo, Maria Norma
Soares, Rodrigo Pedro
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance.
Lapachol [2-hydroxy-3-(3′-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens.
In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides complexes with antimony (V), bismuth (V), and tin (IV) against L.
amazonensis.
All seven compounds exhibited antileishmanial activity, but most of the antimony (V) and bismuth (V) complexes were toxic against human HepG2 cells and murine macrophages.
The best IC50 values (0.17 ± 0.03 and 0.10 ± 0.11 μg/mL) were observed for Tin (IV) complexes (3) [(Lp)(Ph3Sn)] and (6) (Ph3SnCl2), respectively.
Their selective indexes (SIs) were 70.65 and 120.35 for HepG2 cells, respectively.
However, while analyzing murine macrophages, the SI decreased.
Those compounds were moderately toxic for HepG2 cells and toxic for murine macrophages, still underlying the need of chemical modification in this class of compounds.
American Psychological Association (APA)
Rocha, Marcele Neves& Nogueira, Paula Monalisa& Demicheli, Cynthia& de Oliveira, Ludmila Gonçalvez& da Silva, Meiriane Mariano& Frézard, Frédéric…[et al.]. 2013. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511717
Modern Language Association (MLA)
Rocha, Marcele Neves…[et al.]. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-511717
American Medical Association (AMA)
Rocha, Marcele Neves& Nogueira, Paula Monalisa& Demicheli, Cynthia& de Oliveira, Ludmila Gonçalvez& da Silva, Meiriane Mariano& Frézard, Frédéric…[et al.]. Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-511717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511717