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Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome
المؤلفون المشاركون
Feng, Yi
Benrick, Anna
Ohlsson, Claes
Miao, Sun
Duleba, Antoni J.
Stener-Victorin, Elisabet
Maliqueo, Manuel
Villanueva, Jesus A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with obesity and insulin resistance that often precedes the development of type-2 diabetes.
Rats continuously exposed to dihydrotestosterone from prepuberty display typical reproductive and metabolic PCOS characteristics including anovulation, polycystic ovaries, insulin resistance, and obesity.
Our aim was to investigate if resveratrol improves reproductive and metabolic functions in PCOS rats.
The effect was compared to exercise.
Control and PCOS rats were treated with vehicle or resveratrol (400 mg · kg−1 · day−1) for 5-6 weeks.
Another group of PCOS rats received vehicle treatment and exercised for 5-6 weeks.
Insulin sensitivity was determined by euglycemic-hyperinsulinemic clamp.
The glucose infusion rate was lower in the PCOS-vehicle group compared to control-vehicle rats (P<0.05).
Exercise increased insulin sensitivity compared with PCOS-vehicle rats (P<0.05), but resveratrol did not.
Resveratrol treatment and exercise resulted in smaller adipocytes, upregulated estrogen-related receptor α gene expression in subcutaneous fat, and improved estrus cyclicity in the previously acyclic PCOS rats.
Although resveratrol had positive effects on adiposity and cyclicity in a similar manner to exercise, resveratrol does not seem to be a good candidate for treating insulin resistance associated with PCOS because no improvement in insulin sensitivity was observed in PCOS rats on normal chow.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benrick, Anna& Maliqueo, Manuel& Miao, Sun& Villanueva, Jesus A.& Feng, Yi& Ohlsson, Claes…[et al.]. 2013. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benrick, Anna…[et al.]. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-511918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benrick, Anna& Maliqueo, Manuel& Miao, Sun& Villanueva, Jesus A.& Feng, Yi& Ohlsson, Claes…[et al.]. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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