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Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome
Joint Authors
Feng, Yi
Benrick, Anna
Ohlsson, Claes
Miao, Sun
Duleba, Antoni J.
Stener-Victorin, Elisabet
Maliqueo, Manuel
Villanueva, Jesus A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with obesity and insulin resistance that often precedes the development of type-2 diabetes.
Rats continuously exposed to dihydrotestosterone from prepuberty display typical reproductive and metabolic PCOS characteristics including anovulation, polycystic ovaries, insulin resistance, and obesity.
Our aim was to investigate if resveratrol improves reproductive and metabolic functions in PCOS rats.
The effect was compared to exercise.
Control and PCOS rats were treated with vehicle or resveratrol (400 mg · kg−1 · day−1) for 5-6 weeks.
Another group of PCOS rats received vehicle treatment and exercised for 5-6 weeks.
Insulin sensitivity was determined by euglycemic-hyperinsulinemic clamp.
The glucose infusion rate was lower in the PCOS-vehicle group compared to control-vehicle rats (P<0.05).
Exercise increased insulin sensitivity compared with PCOS-vehicle rats (P<0.05), but resveratrol did not.
Resveratrol treatment and exercise resulted in smaller adipocytes, upregulated estrogen-related receptor α gene expression in subcutaneous fat, and improved estrus cyclicity in the previously acyclic PCOS rats.
Although resveratrol had positive effects on adiposity and cyclicity in a similar manner to exercise, resveratrol does not seem to be a good candidate for treating insulin resistance associated with PCOS because no improvement in insulin sensitivity was observed in PCOS rats on normal chow.
American Psychological Association (APA)
Benrick, Anna& Maliqueo, Manuel& Miao, Sun& Villanueva, Jesus A.& Feng, Yi& Ohlsson, Claes…[et al.]. 2013. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511918
Modern Language Association (MLA)
Benrick, Anna…[et al.]. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-511918
American Medical Association (AMA)
Benrick, Anna& Maliqueo, Manuel& Miao, Sun& Villanueva, Jesus A.& Feng, Yi& Ohlsson, Claes…[et al.]. Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511918