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Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
المؤلفون المشاركون
Huang, Chia-Chen
Chou, Chia-Hsuan
Wu, Man-Tzu Marcie
Li, Ying-Ti
Tseng, Tzu-Yen
Chen, Chun-Chieh
Wong, Ruey-Hong
Wang, Tsung-Shing
Tsai, Chun-Cheng
Huang, Chun-Huang
Chang, Fang-Yu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The P-glycoprotein, encoded by the multidrug resistance (MDR)1 gene, extrudes fat-soluble compounds to the extracellular environment.
However, the DNA damage of pesticides in subjects with genetic variation in MDR1 has not been investigated.
In this study, the comet assay was applied to examine the extent of DNA damage in the peripheral blood of 195 fruit growers who had been exposed to pesticides and 141 unexposed controls.
The MDR1 polymorphisms were identified.
Questionnaires were administered to obtain demographic data and occupational history.
Results showed subjects experiencing high (2.14 μm/cell, P<0.01) or low pesticide exposure (2.18 μm/cell, P<0.01) had a significantly greater DNA tail moment than controls (1.28 μm/cell).
Compared to the MDR1 T-129C (rs3213619) TC/CC carriers, the TT carriers had increased DNA tail moment in controls (1.30 versus 1.12 μm/cell, P<0.01).
Similar results were observed in the high and low pesticide-exposed groups.
Combined analysis revealed that pesticide-exposed fruit growers with MDR1 -129 TT genotype had the greatest DNA damage in the subjects with the combinations of pesticide exposure and MDR1 -129 genotypes.
In conclusion, pesticide exposed individuals with susceptible MDR1 -129 genotypes may experience increased risk of DNA damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Chun-Chieh& Huang, Chun-Huang& Wu, Man-Tzu Marcie& Chou, Chia-Hsuan& Huang, Chia-Chen& Tseng, Tzu-Yen…[et al.]. 2014. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Chun-Chieh…[et al.]. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-512069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Chun-Chieh& Huang, Chun-Huang& Wu, Man-Tzu Marcie& Chou, Chia-Hsuan& Huang, Chia-Chen& Tseng, Tzu-Yen…[et al.]. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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