Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
Joint Authors
Huang, Chia-Chen
Chou, Chia-Hsuan
Wu, Man-Tzu Marcie
Li, Ying-Ti
Tseng, Tzu-Yen
Chen, Chun-Chieh
Wong, Ruey-Hong
Wang, Tsung-Shing
Tsai, Chun-Cheng
Huang, Chun-Huang
Chang, Fang-Yu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The P-glycoprotein, encoded by the multidrug resistance (MDR)1 gene, extrudes fat-soluble compounds to the extracellular environment.
However, the DNA damage of pesticides in subjects with genetic variation in MDR1 has not been investigated.
In this study, the comet assay was applied to examine the extent of DNA damage in the peripheral blood of 195 fruit growers who had been exposed to pesticides and 141 unexposed controls.
The MDR1 polymorphisms were identified.
Questionnaires were administered to obtain demographic data and occupational history.
Results showed subjects experiencing high (2.14 μm/cell, P<0.01) or low pesticide exposure (2.18 μm/cell, P<0.01) had a significantly greater DNA tail moment than controls (1.28 μm/cell).
Compared to the MDR1 T-129C (rs3213619) TC/CC carriers, the TT carriers had increased DNA tail moment in controls (1.30 versus 1.12 μm/cell, P<0.01).
Similar results were observed in the high and low pesticide-exposed groups.
Combined analysis revealed that pesticide-exposed fruit growers with MDR1 -129 TT genotype had the greatest DNA damage in the subjects with the combinations of pesticide exposure and MDR1 -129 genotypes.
In conclusion, pesticide exposed individuals with susceptible MDR1 -129 genotypes may experience increased risk of DNA damage.
American Psychological Association (APA)
Chen, Chun-Chieh& Huang, Chun-Huang& Wu, Man-Tzu Marcie& Chou, Chia-Hsuan& Huang, Chia-Chen& Tseng, Tzu-Yen…[et al.]. 2014. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512069
Modern Language Association (MLA)
Chen, Chun-Chieh…[et al.]. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-512069
American Medical Association (AMA)
Chen, Chun-Chieh& Huang, Chun-Huang& Wu, Man-Tzu Marcie& Chou, Chia-Hsuan& Huang, Chia-Chen& Tseng, Tzu-Yen…[et al.]. Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-512069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512069