Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks
المؤلفون المشاركون
Zhou, Yi
Chen, Jianhong
Fang, Qun
Luo, Yan-Min
Chen, Baojiang
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-07-08
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objective.
To compare the difference of imprinting status of insulin-like growth factor II (IGF-II) gene in villus between normal embryo development group and abnormal embryo development group and to investigate the relationship between karyotype and the imprinting status of IGF-II gene.
Methods.
A total of 85 pregnant women with singleton pregnancy were divided into two groups: one with abnormal embryo development (n=38) and the other with normal embryo development (n=47).
Apa I polymorphism of IGF-II gene in chorionic villus was assayed with reverse transcriptase polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP).
The relationship between chromosomal abnormal karyotype and IGF-II gene imprinting status was analyzed by primary cell culture and G-banding chromosomal karyotype analysis.
Results.
IGF-II imprinting loss rate was higher in the abnormal embryo development group than the normal embryo development group (44.7% versus 31.6%), but without significant difference (P>.05).
The percentage of abnormal chromosomes of chorionic villus in the abnormal embryo development group was 42.5%, in which IGF-II imprinting loss rate reached 64.7%.
No abnormal karyotypes were found in the normal embryo development group.
However, there was significant difference in IGF-II imprinting loss rate between two groups (P>.05).
Conclusion.
During weeks 6–10 of gestation, abnormal embryonic development is correlated with chromosomal abnormalities.
The imprinting status of IGF-II gene played important roles in embryonic development, and imprinting loss might be related to chromosomal abnormalities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jianhong& Fang, Qun& Chen, Baojiang& Zhou, Yi& Luo, Yan-Min. 2010. Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-512083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jianhong…[et al.]. Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks. Obstetrics and Gynecology International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-512083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jianhong& Fang, Qun& Chen, Baojiang& Zhou, Yi& Luo, Yan-Min. Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-512083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر