Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia
المؤلفون المشاركون
Ozkinay, Ferda
Irken, Gulersu
Cetingul, Nazan
Gunduz, Cumhur
Kavakli, Kaan
Duyu, Muhterem
Cogulu, Ozgur
Aksoylar, Serap
Vergin, Canan
Durmaz, Burak
Yaman, Yontem
Yilmaz Karapinar, Deniz
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Dysregulation of microRNA (miRNA) expression contributes to the pathogenesis of several clinical conditions.
The aim of this study is to evaluate the associations between miRNAs and childhood acute lymphoblastic leukemia (ALL) to discover their role in the course of the disease.
Forty-three children with ALL and 14 age-matched healthy controls were included in the study.
MicroRNA microarray expression profiling was used for peripheral blood and bone marrow samples.
Aberrant miRNA expressions associated with the diagnosis and outcome were prospectively evaluated.
Confirmation analysis was performed by real time RT-PCR.
miR-128, miR-146a, miR-155, miR-181a, and miR-195 were significantly dysregulated in ALL patients at day 0.
Following a six-month treatment period, the change in miRNA levels was determined by real time RT-PCR and expression of miR-146a, miR-155, miR-181a, and miR-195 significantly decreased.
To conclude, these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duyu, Muhterem& Durmaz, Burak& Gunduz, Cumhur& Vergin, Canan& Yilmaz Karapinar, Deniz& Aksoylar, Serap…[et al.]. 2014. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duyu, Muhterem…[et al.]. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-512144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duyu, Muhterem& Durmaz, Burak& Gunduz, Cumhur& Vergin, Canan& Yilmaz Karapinar, Deniz& Aksoylar, Serap…[et al.]. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر