Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia
Joint Authors
Ozkinay, Ferda
Irken, Gulersu
Cetingul, Nazan
Gunduz, Cumhur
Kavakli, Kaan
Duyu, Muhterem
Cogulu, Ozgur
Aksoylar, Serap
Vergin, Canan
Durmaz, Burak
Yaman, Yontem
Yilmaz Karapinar, Deniz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dysregulation of microRNA (miRNA) expression contributes to the pathogenesis of several clinical conditions.
The aim of this study is to evaluate the associations between miRNAs and childhood acute lymphoblastic leukemia (ALL) to discover their role in the course of the disease.
Forty-three children with ALL and 14 age-matched healthy controls were included in the study.
MicroRNA microarray expression profiling was used for peripheral blood and bone marrow samples.
Aberrant miRNA expressions associated with the diagnosis and outcome were prospectively evaluated.
Confirmation analysis was performed by real time RT-PCR.
miR-128, miR-146a, miR-155, miR-181a, and miR-195 were significantly dysregulated in ALL patients at day 0.
Following a six-month treatment period, the change in miRNA levels was determined by real time RT-PCR and expression of miR-146a, miR-155, miR-181a, and miR-195 significantly decreased.
To conclude, these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis.
American Psychological Association (APA)
Duyu, Muhterem& Durmaz, Burak& Gunduz, Cumhur& Vergin, Canan& Yilmaz Karapinar, Deniz& Aksoylar, Serap…[et al.]. 2014. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512144
Modern Language Association (MLA)
Duyu, Muhterem…[et al.]. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-512144
American Medical Association (AMA)
Duyu, Muhterem& Durmaz, Burak& Gunduz, Cumhur& Vergin, Canan& Yilmaz Karapinar, Deniz& Aksoylar, Serap…[et al.]. Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-512144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512144