Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction
المؤلفون المشاركون
Zhai, Jianying
Ai-Ming, Wu
Wang, Shuoren
Zhu, Lingqun
Yan-Wei, Xing
Hai-Yan, Zhu
Zhao, Mingjing
Chai, Limin
Yong-Hong, Gao
Li-Xia, Lou
Lv, Xiying
Zhang, Dong-mei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To determine the effect of a Chinese herbal compound named Wenxin Granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction (MI).
Methods.
Male Sprague-Dawley (SD) rats were randomly divided into four groups: the control group, the model group, the metoprolol group, and the Wenxin Granule group (WXKL group) with sample size (n) of 7 rats in each group.
An MI model was established in all rats by occlusion of the left anterior descending coronary artery (the control group was without occlusion).
Wenxin Granule (1.35 g/kg/day), metoprolol (12 mg/kg/day), and distilled water (5 mL/kg/day for the control and model groups) were administered orally for 4 weeks.
Ultrasonic echocardiography was used to examine cardiac structural and functional parameters.
Myocardial histopathological changes were observed using haematoxylin and eosin (H&E) dyeing.
Myocardial apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining.
Serum angiotensin II (Ang II) concentration was measured using the enzyme-linked immunosorbent assay (ELISA).
Results.
It was found that Wenxin Granule could partially reverse ventricular remodeling, improve heart function, alleviate the histopathological damage, inhibit myocardial apoptosis, and reduce Ang II concentration in rats with MI.
Conclusions.
The results of the current study suggest that Wenxin Granule may be a potential alternative and complementary medicine for the treatment of MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ai-Ming, Wu& Zhai, Jianying& Zhang, Dong-mei& Li-Xia, Lou& Hai-Yan, Zhu& Yong-Hong, Gao…[et al.]. 2013. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ai-Ming, Wu…[et al.]. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-512162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ai-Ming, Wu& Zhai, Jianying& Zhang, Dong-mei& Li-Xia, Lou& Hai-Yan, Zhu& Yong-Hong, Gao…[et al.]. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر