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Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction
Joint Authors
Zhai, Jianying
Ai-Ming, Wu
Wang, Shuoren
Zhu, Lingqun
Yan-Wei, Xing
Hai-Yan, Zhu
Zhao, Mingjing
Chai, Limin
Yong-Hong, Gao
Li-Xia, Lou
Lv, Xiying
Zhang, Dong-mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To determine the effect of a Chinese herbal compound named Wenxin Granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction (MI).
Methods.
Male Sprague-Dawley (SD) rats were randomly divided into four groups: the control group, the model group, the metoprolol group, and the Wenxin Granule group (WXKL group) with sample size (n) of 7 rats in each group.
An MI model was established in all rats by occlusion of the left anterior descending coronary artery (the control group was without occlusion).
Wenxin Granule (1.35 g/kg/day), metoprolol (12 mg/kg/day), and distilled water (5 mL/kg/day for the control and model groups) were administered orally for 4 weeks.
Ultrasonic echocardiography was used to examine cardiac structural and functional parameters.
Myocardial histopathological changes were observed using haematoxylin and eosin (H&E) dyeing.
Myocardial apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining.
Serum angiotensin II (Ang II) concentration was measured using the enzyme-linked immunosorbent assay (ELISA).
Results.
It was found that Wenxin Granule could partially reverse ventricular remodeling, improve heart function, alleviate the histopathological damage, inhibit myocardial apoptosis, and reduce Ang II concentration in rats with MI.
Conclusions.
The results of the current study suggest that Wenxin Granule may be a potential alternative and complementary medicine for the treatment of MI.
American Psychological Association (APA)
Ai-Ming, Wu& Zhai, Jianying& Zhang, Dong-mei& Li-Xia, Lou& Hai-Yan, Zhu& Yong-Hong, Gao…[et al.]. 2013. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512162
Modern Language Association (MLA)
Ai-Ming, Wu…[et al.]. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-512162
American Medical Association (AMA)
Ai-Ming, Wu& Zhai, Jianying& Zhang, Dong-mei& Li-Xia, Lou& Hai-Yan, Zhu& Yong-Hong, Gao…[et al.]. Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-512162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512162