Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain
المؤلفون المشاركون
Chen, Zhiwei
Huang, Xiaoxing
Wang, Haibo
Yu, Wenbo
Lu, Bin
Liu, Li
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The possible bioterrorism threat using the variola virus, the causative agent of smallpox, has promoted us to further investigate the immunogenicity profiles of existing vaccines.
Here, we study for the first time the immunogenicity profile of a replication-competent smallpox vaccine (vaccinia Tiantan, VTT strain) for inducing neutralizing antibodies (Nabs) through mucosal vaccination, which is noninvasive and has a critical implication for massive vaccination programs.
Four different routes of vaccination were tested in parallel including intramuscular (i.m.), intranasal (i.n.), oral (i.o.), and subcutaneous (s.c.) inoculations in mice.
We found that one time vaccination with an optimal dose of VTT was able to induce anti-VTT Nabs via each of the four routes.
Higher levels of antiviral Nabs, however, were induced via the i.n.
and i.o.
inoculations when compared with the i.m.
and s.c.
routes.
Moreover, the i.n.
and i.o.
vaccinations also induced higher sustained levels of Nabs overtime, which conferred better protections against homologous or alternating mucosal routes of viral challenges six months post vaccination.
The VTT-induced immunity via all four routes, however, was partially effective against the intramuscular viral challenge.
Our data have implications for understanding the potential application of mucosal smallpox vaccination and for developing VTT-based vaccines to overcome preexisting antivaccinia immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Bin& Yu, Wenbo& Huang, Xiaoxing& Wang, Haibo& Liu, Li& Chen, Zhiwei. 2011. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Bin…[et al.]. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-512345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Bin& Yu, Wenbo& Huang, Xiaoxing& Wang, Haibo& Liu, Li& Chen, Zhiwei. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر