Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain
Joint Authors
Chen, Zhiwei
Huang, Xiaoxing
Wang, Haibo
Yu, Wenbo
Lu, Bin
Liu, Li
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The possible bioterrorism threat using the variola virus, the causative agent of smallpox, has promoted us to further investigate the immunogenicity profiles of existing vaccines.
Here, we study for the first time the immunogenicity profile of a replication-competent smallpox vaccine (vaccinia Tiantan, VTT strain) for inducing neutralizing antibodies (Nabs) through mucosal vaccination, which is noninvasive and has a critical implication for massive vaccination programs.
Four different routes of vaccination were tested in parallel including intramuscular (i.m.), intranasal (i.n.), oral (i.o.), and subcutaneous (s.c.) inoculations in mice.
We found that one time vaccination with an optimal dose of VTT was able to induce anti-VTT Nabs via each of the four routes.
Higher levels of antiviral Nabs, however, were induced via the i.n.
and i.o.
inoculations when compared with the i.m.
and s.c.
routes.
Moreover, the i.n.
and i.o.
vaccinations also induced higher sustained levels of Nabs overtime, which conferred better protections against homologous or alternating mucosal routes of viral challenges six months post vaccination.
The VTT-induced immunity via all four routes, however, was partially effective against the intramuscular viral challenge.
Our data have implications for understanding the potential application of mucosal smallpox vaccination and for developing VTT-based vaccines to overcome preexisting antivaccinia immunity.
American Psychological Association (APA)
Lu, Bin& Yu, Wenbo& Huang, Xiaoxing& Wang, Haibo& Liu, Li& Chen, Zhiwei. 2011. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512345
Modern Language Association (MLA)
Lu, Bin…[et al.]. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-512345
American Medical Association (AMA)
Lu, Bin& Yu, Wenbo& Huang, Xiaoxing& Wang, Haibo& Liu, Li& Chen, Zhiwei. Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine : Vaccinia Tiantan Strain. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-512345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512345