Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3KAkt Pathway
المؤلفون المشاركون
Xu, Zhi-Wei
Wu, Wei-Kang
Liao, Xin-Xue
Chen, Yan-Ling
Guo, Hua-Lei
Zhuang, Xiao-Dong
Lu, Li-He
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Sini decoction is a well-known formula of traditional Chinese medicine, which has been used to treat cardiovascular disease for many years.
Previously, we demonstrated that Sini decoction prevented doxorubicin-induced heart failure in vivo.
However, its active components are still unclear.
Thus, we investigated the active components of Sini decoction and their cardioprotective mechanisms in the in vitro neonatal rat cardiomyocytes and H9c2 cell line models of doxorubicin-induced cytotoxicity.
Our results demonstrated that treatment with higenamine or [6]-gingerol increased viability of doxorubicine-injured cardiomyocytes.
Moreover, combined use of higenamine and [6]-gingerol exerted more profound protective effects than either drug as a single agent, with effects similar to those of dexrazoxane, a clinically approved cardiac protective agent.
In addition, we found that treatment with doxorubicin reduced SOD activity, increased ROS generation, enhanced MDA formation, induced release of LDH, and triggered the intrinsic mitochondria-dependent apoptotic pathway in cardiomyocytes, which was inhibited by cotreatment of higenamine and [6]-gingerol.
Most importantly, the cytoprotection of higenamine plus [6]-gingerol could be abrogated by LY294002, a PI3K inhibitor.
In conclusion, combination of higenamine and [6]-gingerol exerts cardioprotective effect against doxorubicin-induced cardiotoxicity through activating the PI3K/Akt signaling pathway.
Higenamine and [6]-gingerol may be the active components of Sini decoction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yan-Ling& Zhuang, Xiao-Dong& Xu, Zhi-Wei& Lu, Li-He& Guo, Hua-Lei& Wu, Wei-Kang…[et al.]. 2013. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-512355
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yan-Ling…[et al.]. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-512355
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yan-Ling& Zhuang, Xiao-Dong& Xu, Zhi-Wei& Lu, Li-He& Guo, Hua-Lei& Wu, Wei-Kang…[et al.]. Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-512355
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512355
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر