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CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat
المؤلفون المشاركون
Xiao, Li
Zhao, Hongyu
Zheng, Qiang
Liu, Zhenning
Wang, Yu
Zhao, Min
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Paraquat, a widely used herbicide, is well known to exhibit oxidative stress and lung injury.
In the present study, we investigated the possible underlying mechanisms of cannabinoid receptor-2 (CB2) activation to ameliorate the proinflammatory activity induced by PQ in rats.
JWH133, a CB2 agonist, was administered by intraperitoneal injection 1 h prior to PQ exposure.
After PQ exposure for 4, 8, 24, and 72 h, the bronchoalveolar lavage fluid was collected to determine levels of TNF-α and IL-1β, and the arterial blood samples were collected for detection of PaO2 level.
At 72 h after PQ exposure, lung tissues were collected to determine the lung wet-to-dry weight ratios, myeloperoxidase activity, lung histopathology, the protein expression level of CB2, MAPKs (ERK1/2, p38MAPK, and JNK1/2), and NF-κBp65.
After rats were pretreated with JWH133, PQ-induced lung edema and lung histopathological changes were significantly attenuated.
PQ-induced TNF-α and IL-1β secretion in BALF, increases of PaO2 in arterial blood, and MPO levels in the lung tissue were significantly reduced.
JWH133 could efficiently activate CB2, while inhibiting MAPKs and NF-κB activation.
The results suggested that activating CB2 receptor exerted protective activity against PQ-induced ALI, and it potentially contributed to the suppression of the activation of MAPKs and NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhenning& Wang, Yu& Zhao, Hongyu& Zheng, Qiang& Xiao, Li& Zhao, Min. 2014. CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-512482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhenning…[et al.]. CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-512482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhenning& Wang, Yu& Zhao, Hongyu& Zheng, Qiang& Xiao, Li& Zhao, Min. CB2 Receptor Activation Ameliorates the Proinflammatory Activity in Acute Lung Injury Induced by Paraquat. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-512482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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