Dissection of Mechanisms of a Chinese Medicinal Formula : Danhong Injection Therapy for Myocardial IschemiaReperfusion Injury In Vivo and In Vitro
المؤلفون المشاركون
Duan, Jia-Lin
Quan, Wei
Guan, Yue
Guo, Chao
Yin, Ying
Wang, Yan-Hua
Wei, Guo
Zhu, Yan-rong
Wen, Ai-Dong
Weng, Yan
Zhou, Dan
Xi, Miao-Miao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine uses a systemic treatment approach, targeting multiple etiological factors simultaneously.
Danhong injection (DHI), a very popular Chinese medicine injection, is reported to be effective for many cardiovascular conditions.
The primary active ingredients of DHI, and their systemic and interrelated mechanism have not been evaluated in an established myocardial ischemia/reperfusion (MI/R) model.
We identified the main active constituents in DHI, including hydroxysafflor yellow A (A), salvianolic acid B (B), and danshensu (C), by HPLC fingerprint analysis and assessed their effect on MI/R rats and cardiomyocytes.
These 3 compounds and DHI all decreased the levels of IL-1, TNF-α, and MDA, increased those of IL-10 and SOD activity in vivo and in vitro, and had antiapoptotic effects, as shown by flow cytometric analysis and TUNEL assay.
Moreover, these compounds increased phosphorylation of Akt and ERK1/2 in cardiomyocytes.
Interestingly, we found compound A exerted a more prominent anti-inflammatory effect than B and C, by decreasing NF-κB levels; compound B had more powerful antioxidative capacity than A and C, by increasing Nrf2 expression; compound C had stronger antiapoptotic ability than A and B, by lowering caspase-3 activity.
Our results elucidate the mechanisms by which DHI protects against MI/R induced injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guan, Yue& Yin, Ying& Zhu, Yan-rong& Guo, Chao& Wei, Guo& Duan, Jia-Lin…[et al.]. 2013. Dissection of Mechanisms of a Chinese Medicinal Formula : Danhong Injection Therapy for Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guan, Yue…[et al.]. Dissection of Mechanisms of a Chinese Medicinal Formula : Danhong Injection Therapy for Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-512536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guan, Yue& Yin, Ying& Zhu, Yan-rong& Guo, Chao& Wei, Guo& Duan, Jia-Lin…[et al.]. Dissection of Mechanisms of a Chinese Medicinal Formula : Danhong Injection Therapy for Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر