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Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation
المؤلفون المشاركون
Chong, Si Jack
Wong, Yong Chiat
Wu, Jian
Lu, Jia
Moochhala, Shabbir M.
Tan, Mui Hong
المصدر
International Journal of Inflammation
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Burn injuries result in the release of proinflammatory mediators causing both local and systemic inflammation.
Multiple organ dysfunctions secondary to systemic inflammation after severe burn contribute to adverse outcome, with the lungs being the first organ to fail.
In this study, we evaluate the anti-inflammatory effects of Parecoxib, a parenteral COX-2 inhibitor, in a delayed fluid resuscitation burned rat model.
Anaesthetized Sprague Dawley rats were inflicted with 45% total body surface area full-thickness scald burns and subsequently subjected to delayed resuscitation with Hartmann’s solution.
Parecoxib (0.1, 1.0, and 10 mg/kg) was delivered intramuscularly 20 min after injury followed by 12 h interval and the rats were sacrificed at 6 h, 24 h, and 48 h.
Burn rats developed elevated blood cytokines, transaminase, creatinine, and increased lung MPO levels.
Animals treated with 1 mg/kg Parecoxib showed significantly reduced plasma level of CINC-1, IL-6, PGEM, and lung MPO.
Treatment of 1 mg/kg Parecoxib is shown to mitigate systemic and lung inflammation without significantly affecting other organs.
At present, no specific therapeutic agent is available to attenuate the systemic inflammatory response secondary to burn injury.
The results suggest that Parecoxib may have the potential to be used both as an analgesic and ameliorate the effects of lung injury following burn.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chong, Si Jack& Wong, Yong Chiat& Wu, Jian& Tan, Mui Hong& Lu, Jia& Moochhala, Shabbir M.. 2014. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chong, Si Jack…[et al.]. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-512576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chong, Si Jack& Wong, Yong Chiat& Wu, Jian& Tan, Mui Hong& Lu, Jia& Moochhala, Shabbir M.. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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