Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation
Joint Authors
Chong, Si Jack
Wong, Yong Chiat
Wu, Jian
Lu, Jia
Moochhala, Shabbir M.
Tan, Mui Hong
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Burn injuries result in the release of proinflammatory mediators causing both local and systemic inflammation.
Multiple organ dysfunctions secondary to systemic inflammation after severe burn contribute to adverse outcome, with the lungs being the first organ to fail.
In this study, we evaluate the anti-inflammatory effects of Parecoxib, a parenteral COX-2 inhibitor, in a delayed fluid resuscitation burned rat model.
Anaesthetized Sprague Dawley rats were inflicted with 45% total body surface area full-thickness scald burns and subsequently subjected to delayed resuscitation with Hartmann’s solution.
Parecoxib (0.1, 1.0, and 10 mg/kg) was delivered intramuscularly 20 min after injury followed by 12 h interval and the rats were sacrificed at 6 h, 24 h, and 48 h.
Burn rats developed elevated blood cytokines, transaminase, creatinine, and increased lung MPO levels.
Animals treated with 1 mg/kg Parecoxib showed significantly reduced plasma level of CINC-1, IL-6, PGEM, and lung MPO.
Treatment of 1 mg/kg Parecoxib is shown to mitigate systemic and lung inflammation without significantly affecting other organs.
At present, no specific therapeutic agent is available to attenuate the systemic inflammatory response secondary to burn injury.
The results suggest that Parecoxib may have the potential to be used both as an analgesic and ameliorate the effects of lung injury following burn.
American Psychological Association (APA)
Chong, Si Jack& Wong, Yong Chiat& Wu, Jian& Tan, Mui Hong& Lu, Jia& Moochhala, Shabbir M.. 2014. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512576
Modern Language Association (MLA)
Chong, Si Jack…[et al.]. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-512576
American Medical Association (AMA)
Chong, Si Jack& Wong, Yong Chiat& Wu, Jian& Tan, Mui Hong& Lu, Jia& Moochhala, Shabbir M.. Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512576