Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice
المؤلفون المشاركون
Willemin, Gilles
Bauduret, Armelle
Minehira, Kaori
Roger, Catherine
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Single-nucleotide polymorphisms within major histocompatibility class II (MHC II) genes have been associated with an increased risk of drug-induced liver injury.
However, it has never been addressed whether the MHC II pathway plays an important role in the development of nonalcoholic fatty liver disease, the most common form of liver disease.
We used a mouse model that has a complete knockdown of genes in the MHC II pathway (MHCIIΔ/Δ).
Firstly we studied the effect of high-fat diet-induced hepatic inflammation in these mice.
Secondly we studied the development of carbon-tetra-chloride- (CCl4-) induced hepatic cirrhosis.
After the high-fat diet, both groups developed obesity and hepatic steatosis with a similar degree of hepatic inflammation, suggesting no impact of the knockdown of MHC II on high-fat diet-induced inflammation in mice.
In the second study, we confirmed that the CCl4 injection significantly upregulated the MHC II genes in wild-type mice.
The CCl4 treatment significantly induced genes related to the fibrosis formation in wild-type mice, whereas this was lower in MHCIIΔ/Δ mice.
The liver histology, however, showed no detectable difference between groups, suggesting that the MHC II pathway is not required for the development of hepatic fibrosis induced by CCl4.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Willemin, Gilles& Roger, Catherine& Bauduret, Armelle& Minehira, Kaori. 2013. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Willemin, Gilles…[et al.]. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-512615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Willemin, Gilles& Roger, Catherine& Bauduret, Armelle& Minehira, Kaori. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر