Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice
Joint Authors
Willemin, Gilles
Bauduret, Armelle
Minehira, Kaori
Roger, Catherine
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Single-nucleotide polymorphisms within major histocompatibility class II (MHC II) genes have been associated with an increased risk of drug-induced liver injury.
However, it has never been addressed whether the MHC II pathway plays an important role in the development of nonalcoholic fatty liver disease, the most common form of liver disease.
We used a mouse model that has a complete knockdown of genes in the MHC II pathway (MHCIIΔ/Δ).
Firstly we studied the effect of high-fat diet-induced hepatic inflammation in these mice.
Secondly we studied the development of carbon-tetra-chloride- (CCl4-) induced hepatic cirrhosis.
After the high-fat diet, both groups developed obesity and hepatic steatosis with a similar degree of hepatic inflammation, suggesting no impact of the knockdown of MHC II on high-fat diet-induced inflammation in mice.
In the second study, we confirmed that the CCl4 injection significantly upregulated the MHC II genes in wild-type mice.
The CCl4 treatment significantly induced genes related to the fibrosis formation in wild-type mice, whereas this was lower in MHCIIΔ/Δ mice.
The liver histology, however, showed no detectable difference between groups, suggesting that the MHC II pathway is not required for the development of hepatic fibrosis induced by CCl4.
American Psychological Association (APA)
Willemin, Gilles& Roger, Catherine& Bauduret, Armelle& Minehira, Kaori. 2013. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512615
Modern Language Association (MLA)
Willemin, Gilles…[et al.]. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-512615
American Medical Association (AMA)
Willemin, Gilles& Roger, Catherine& Bauduret, Armelle& Minehira, Kaori. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512615