Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity
المؤلفون المشاركون
Barret, Luc
Lamarche, Frédéric
Nuiry, Laurence
Allibe, Nathalie
Gonthier, Brigitte
Cottet-Rousselle, Cécile
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الطب البشري
الملخص EN
Aims.
3,5,4′-Trihydroxy-trans-stilbene, a natural polyphenolic compound present in wine and grapes and better known as resveratrol, has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism.
Today, the mechanism by which ethanol exerts its toxicity is still not well understood, but it is generally considered that free radical generation plays an important role in the appearance of structural and functional alterations in cells.
The aim of this study was to evaluate the protective action of resveratrol against ethanol-induced brain cell injury.
Methods.
Primary cultures of rat astrocytes were exposed to ethanol, with or without a pretreatment with resveratrol.
We examined the dose-dependent effects of this resveratrol pretreatment on cytotoxicity and genotoxicity induced by ethanol.
Cytotoxicity was assessed using the MTT reduction test.
Genotoxicity was evidenced using single cell gel electrophoresis.
In addition, DNA staining with fluorescent dyes allowed visualization of nuclear damage using confocal microscopy.
Results.
Cell pretreatment with low concentrations of trans-resveratrol (0.1–10 μM) slowed down cell death and DNA damage induced by ethanol exposure, while higher concentrations (50–100 μM) enhanced these same effects.
No protection by cis-resveratrol was observed.
Conclusion.
Protection offered by trans-resveratrol against ethanol-induced neurotoxicity was only effective for low concentrations of this polyphenol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gonthier, Brigitte& Allibe, Nathalie& Cottet-Rousselle, Cécile& Lamarche, Frédéric& Nuiry, Laurence& Barret, Luc. 2012. Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512629
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gonthier, Brigitte…[et al.]. Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity. Journal of Toxicology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-512629
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gonthier, Brigitte& Allibe, Nathalie& Cottet-Rousselle, Cécile& Lamarche, Frédéric& Nuiry, Laurence& Barret, Luc. Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512629
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512629
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر