Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products

المؤلفون المشاركون

Mazur, Bogdan
Kasperska-Zając, Alicja
Grzanka, Alicja
Szumska, Magdalena
Damasiewicz-Bodzek, Aleksandra
Tyrpień-Golder, Krystyna
Machura, Edyta

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-11

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response.

On the other hand, it is known that systemic inflammation may lead to increased formation of advanced glycation end-products (AGEs), associated with pathogenesis of various diseases.

Aim.

We aim to test whether chronic inflammation manifested by activated acute phase response may provide a mechanism for increased serum AGEs concentration in CSU.

Methods.

Concentrations of AGEs were measured spectrofluorimetrically in serum of CSU patients and the healthy subjects.

Results.

Serum AGEs and albumin concentrations in CSU patients were significantly lower as compared with the healthy subjects.

Serum CRP concentration was significantly higher in patients with CSU than in the controls.

Significant positive correlation was observed between AGEs and albumin concentrations in the subjects.

Conclusions.

CSU is not associated with increased circulating AGEs concentrations, despite the enhanced systemic inflammatory response.

Paradoxical decrease of serum AGEs concentrations is probably a reflection of lower concentration of “negative acute phase proteins” such as albumin.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Grzanka, Alicja& Damasiewicz-Bodzek, Aleksandra& Machura, Edyta& Szumska, Magdalena& Tyrpień-Golder, Krystyna& Mazur, Bogdan…[et al.]. 2014. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-512740

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Grzanka, Alicja…[et al.]. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-512740

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Grzanka, Alicja& Damasiewicz-Bodzek, Aleksandra& Machura, Edyta& Szumska, Magdalena& Tyrpień-Golder, Krystyna& Mazur, Bogdan…[et al.]. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-512740

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-512740