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Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products
Joint Authors
Mazur, Bogdan
Kasperska-Zając, Alicja
Grzanka, Alicja
Szumska, Magdalena
Damasiewicz-Bodzek, Aleksandra
Tyrpień-Golder, Krystyna
Machura, Edyta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response.
On the other hand, it is known that systemic inflammation may lead to increased formation of advanced glycation end-products (AGEs), associated with pathogenesis of various diseases.
Aim.
We aim to test whether chronic inflammation manifested by activated acute phase response may provide a mechanism for increased serum AGEs concentration in CSU.
Methods.
Concentrations of AGEs were measured spectrofluorimetrically in serum of CSU patients and the healthy subjects.
Results.
Serum AGEs and albumin concentrations in CSU patients were significantly lower as compared with the healthy subjects.
Serum CRP concentration was significantly higher in patients with CSU than in the controls.
Significant positive correlation was observed between AGEs and albumin concentrations in the subjects.
Conclusions.
CSU is not associated with increased circulating AGEs concentrations, despite the enhanced systemic inflammatory response.
Paradoxical decrease of serum AGEs concentrations is probably a reflection of lower concentration of “negative acute phase proteins” such as albumin.
American Psychological Association (APA)
Grzanka, Alicja& Damasiewicz-Bodzek, Aleksandra& Machura, Edyta& Szumska, Magdalena& Tyrpień-Golder, Krystyna& Mazur, Bogdan…[et al.]. 2014. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-512740
Modern Language Association (MLA)
Grzanka, Alicja…[et al.]. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-512740
American Medical Association (AMA)
Grzanka, Alicja& Damasiewicz-Bodzek, Aleksandra& Machura, Edyta& Szumska, Magdalena& Tyrpień-Golder, Krystyna& Mazur, Bogdan…[et al.]. Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-512740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512740