Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies

المؤلفون المشاركون

Mieszkowski, Jan
Dobek, Aleksandra
Garczynski, Wojciech
Lubkowska, Anna
Chlubek, Dariusz

المصدر

Disease Markers

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-01-23

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأمراض

الملخص EN

The literature reports indicating a link between plasma levels of adiponectin and body fat, bone mineral density, sex hormones, and peri- and postmenopausal changes, draw attention to the possible use of adiponectin as an indicator of osteoporotic changes, suggesting that adiponectin may also modulate bone metabolism.

In this study, we attempted to analyze the available in vitro and in vivo results which could verify this hypothesis.

Although several studies have shown that adiponectin has an adverse effect on bone mass, mainly by intensifying resorption, this peptide has also been demonstrated to increase the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and reduce bone resorption.

There are still many ambiguities; for example, it can be assumed that concentrations of adiponectin in plasma do not satisfactorily reflect its production by adipose tissue, as well as conflicting in vitro and in vivo results.

It seems that the potential benefit in the treatment of patients with osteoporosis associated with the pharmacological regulation of adiponectin is controversial.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lubkowska, Anna& Dobek, Aleksandra& Mieszkowski, Jan& Garczynski, Wojciech& Chlubek, Dariusz. 2014. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-512827

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lubkowska, Anna…[et al.]. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-512827

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lubkowska, Anna& Dobek, Aleksandra& Mieszkowski, Jan& Garczynski, Wojciech& Chlubek, Dariusz. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-512827

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-512827