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Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies
Joint Authors
Mieszkowski, Jan
Dobek, Aleksandra
Garczynski, Wojciech
Lubkowska, Anna
Chlubek, Dariusz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The literature reports indicating a link between plasma levels of adiponectin and body fat, bone mineral density, sex hormones, and peri- and postmenopausal changes, draw attention to the possible use of adiponectin as an indicator of osteoporotic changes, suggesting that adiponectin may also modulate bone metabolism.
In this study, we attempted to analyze the available in vitro and in vivo results which could verify this hypothesis.
Although several studies have shown that adiponectin has an adverse effect on bone mass, mainly by intensifying resorption, this peptide has also been demonstrated to increase the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and reduce bone resorption.
There are still many ambiguities; for example, it can be assumed that concentrations of adiponectin in plasma do not satisfactorily reflect its production by adipose tissue, as well as conflicting in vitro and in vivo results.
It seems that the potential benefit in the treatment of patients with osteoporosis associated with the pharmacological regulation of adiponectin is controversial.
American Psychological Association (APA)
Lubkowska, Anna& Dobek, Aleksandra& Mieszkowski, Jan& Garczynski, Wojciech& Chlubek, Dariusz. 2014. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-512827
Modern Language Association (MLA)
Lubkowska, Anna…[et al.]. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-512827
American Medical Association (AMA)
Lubkowska, Anna& Dobek, Aleksandra& Mieszkowski, Jan& Garczynski, Wojciech& Chlubek, Dariusz. Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women : Controversies. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-512827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512827