Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility
المؤلفون المشاركون
Song, Won-Hee
Yi, Young-Joo
Sutovsky, Peter
Ballard, John William Oman
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-17
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis.
Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals.
In general, high levels of mitochondrial heteroplasmy might contribute to a detrimental effect on fitness and disease resistance.
Therefore, a disposal of the sperm-derived mitochondria inside fertilized oocytes assures normal preimplantation embryo development.
Here we summarize the current research and knowledge concerning the role of autophagic pathway and ubiquitin-proteasome-dependent proteolysis in sperm mitophagy in mammals, including humans.
Current data indicate that sperm mitophagy inside the fertilized oocyte could occur along multiple degradation routes converging on autophagic clearance of paternal mitochondria.
The influence of assisted reproductive therapies (ART) such as intracytoplasmic sperm injection (ICSI), mitochondrial replacement (MR), and assisted fertilization of oocytes from patients of advanced reproductive age on mitochondrial function, inheritance, and fitness and for the development and health of ART babies will be of particular interest to clinical audiences.
Altogether, the study of sperm mitophagy after fertilization has implications in the timing of evolution and developmental and reproductive biology and in human health, fitness, and management of mitochondrial disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Won-Hee& Ballard, John William Oman& Yi, Young-Joo& Sutovsky, Peter. 2014. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-513346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Won-Hee…[et al.]. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-513346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Won-Hee& Ballard, John William Oman& Yi, Young-Joo& Sutovsky, Peter. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-513346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر