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Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility
Joint Authors
Song, Won-Hee
Yi, Young-Joo
Sutovsky, Peter
Ballard, John William Oman
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Mitochondria, the energy-generating organelles, play a role in numerous cellular functions including adenosine triphosphate (ATP) production, cellular homeostasis, and apoptosis.
Maternal inheritance of mitochondria and mitochondrial DNA (mtDNA) is universally observed in humans and most animals.
In general, high levels of mitochondrial heteroplasmy might contribute to a detrimental effect on fitness and disease resistance.
Therefore, a disposal of the sperm-derived mitochondria inside fertilized oocytes assures normal preimplantation embryo development.
Here we summarize the current research and knowledge concerning the role of autophagic pathway and ubiquitin-proteasome-dependent proteolysis in sperm mitophagy in mammals, including humans.
Current data indicate that sperm mitophagy inside the fertilized oocyte could occur along multiple degradation routes converging on autophagic clearance of paternal mitochondria.
The influence of assisted reproductive therapies (ART) such as intracytoplasmic sperm injection (ICSI), mitochondrial replacement (MR), and assisted fertilization of oocytes from patients of advanced reproductive age on mitochondrial function, inheritance, and fitness and for the development and health of ART babies will be of particular interest to clinical audiences.
Altogether, the study of sperm mitophagy after fertilization has implications in the timing of evolution and developmental and reproductive biology and in human health, fitness, and management of mitochondrial disease.
American Psychological Association (APA)
Song, Won-Hee& Ballard, John William Oman& Yi, Young-Joo& Sutovsky, Peter. 2014. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-513346
Modern Language Association (MLA)
Song, Won-Hee…[et al.]. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-513346
American Medical Association (AMA)
Song, Won-Hee& Ballard, John William Oman& Yi, Young-Joo& Sutovsky, Peter. Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System : Implications for Health, Fitness, and Fertility. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-513346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513346