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Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells
المؤلفون المشاركون
Lai, Tung-Yuan
Chuang, Shuang-En
Liu, Chun-Yen
Yang, Chia-Ming
Chen, Suz-Wen
Lai, Gi-Ming
Yao, Chih-Jung
Yan, Kun-Huang
Yan, Jiann-Long
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Tien-Hsien Liquid (THL) is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade.
Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro.
However, the underlying molecular mechanisms have not yet been well elucidated.
In this study, we explored the effects of THL on acute promyelocytic leukemia (APL) NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide.
The results showed THL could induce G2/M arrest and apoptosis in NB4 cells.
Accordingly, the decrease of cyclin A and B1 were observed in THL-treated cells.
The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARα fusion protein.
Moreover, DNA methyltransferase 1 and oncogenic signaling pathways such as Akt/mTOR, Stat3 and ERK were also down-regulated by THL.
By using ethyl acetate extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated.
At about 0.5–1% of the dose of THL, EAS5 appeared to have most of THL-induced multiple molecular targeting effects in NB4 cells.
Based on the findings of these multi-targeting effects, THL might be regarding as a complementary and alternative therapeutic agent for refractory APL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Chih-Jung& Yang, Chia-Ming& Chuang, Shuang-En& Yan, Jiann-Long& Liu, Chun-Yen& Chen, Suz-Wen…[et al.]. 2011. Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Chih-Jung…[et al.]. Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-513563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Chih-Jung& Yang, Chia-Ming& Chuang, Shuang-En& Yan, Jiann-Long& Liu, Chun-Yen& Chen, Suz-Wen…[et al.]. Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-513563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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