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Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats
المؤلفون المشاركون
Marnewick, Jeanine L.
Katengua-Thamahane, Emma
Van Rooyen, Jacques
Ajuwon, Olawale R.
Oguntibeju, Oluwafemi O.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-18
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated.
tert-butyl hydroperoxide caused a significant (P<0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P<0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver.
This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH).
Supplementation with rooibos, RPO, or their combination significantly (P<0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH.
Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed.
The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic.
Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ajuwon, Olawale R.& Katengua-Thamahane, Emma& Van Rooyen, Jacques& Oguntibeju, Oluwafemi O.& Marnewick, Jeanine L.. 2013. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-513580
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ajuwon, Olawale R.…[et al.]. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-513580
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ajuwon, Olawale R.& Katengua-Thamahane, Emma& Van Rooyen, Jacques& Oguntibeju, Oluwafemi O.& Marnewick, Jeanine L.. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-513580
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513580
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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