Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats
Joint Authors
Marnewick, Jeanine L.
Katengua-Thamahane, Emma
Van Rooyen, Jacques
Ajuwon, Olawale R.
Oguntibeju, Oluwafemi O.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated.
tert-butyl hydroperoxide caused a significant (P<0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P<0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver.
This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH).
Supplementation with rooibos, RPO, or their combination significantly (P<0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH.
Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed.
The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic.
Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.
American Psychological Association (APA)
Ajuwon, Olawale R.& Katengua-Thamahane, Emma& Van Rooyen, Jacques& Oguntibeju, Oluwafemi O.& Marnewick, Jeanine L.. 2013. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-513580
Modern Language Association (MLA)
Ajuwon, Olawale R.…[et al.]. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-513580
American Medical Association (AMA)
Ajuwon, Olawale R.& Katengua-Thamahane, Emma& Van Rooyen, Jacques& Oguntibeju, Oluwafemi O.& Marnewick, Jeanine L.. Protective Effects of Rooibos (Aspalathus linearis) andor Red Palm Oil (Elaeis guineensis) Supplementation on tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-513580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513580