The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid
المؤلفون المشاركون
Waring, Jeffrey F.
Ellis, Teresa A.
Li, Jinhe
LeBlond, David
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-08
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Alzheimer's disease (AD), which is characterized by a degeneration of neurons and their synapses, is one of the most common forms of dementia.
CSF levels of amyloid β42 (Aβ42) have been recognized as a strong candidate to serve as an AD biomarker.
There are a number of commercial assays that are routinely employed for measuring Aβ42; however, these assays give diverse ranges for the absolute levels of CSF Aβ42.
In order to employ CSF Aβ42 as a biomarker across multiple laboratories, studies need to be performed to understand the relationship between the different platforms.
We have analyzed CSF samples from both diseased and nondiseased subjects with two different widely used assay platforms.
The results showed that different values for the levels of CSF Aβ42 were reported, depending on the assay used.
Nonetheless, both assays clearly demonstrated statistically significant differences in the levels of Aβ42 in CSF from AD relative to age-matched controls (AMC).
This paper provides essential data for establishing the relationship between these assays and provides an important step towards the validation of Aβ42 as a biomarker for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ellis, Teresa A.& Li, Jinhe& LeBlond, David& Waring, Jeffrey F.. 2012. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-513628
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ellis, Teresa A.…[et al.]. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-513628
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ellis, Teresa A.& Li, Jinhe& LeBlond, David& Waring, Jeffrey F.. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-513628
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513628
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر