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The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid
Joint Authors
Waring, Jeffrey F.
Ellis, Teresa A.
Li, Jinhe
LeBlond, David
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Alzheimer's disease (AD), which is characterized by a degeneration of neurons and their synapses, is one of the most common forms of dementia.
CSF levels of amyloid β42 (Aβ42) have been recognized as a strong candidate to serve as an AD biomarker.
There are a number of commercial assays that are routinely employed for measuring Aβ42; however, these assays give diverse ranges for the absolute levels of CSF Aβ42.
In order to employ CSF Aβ42 as a biomarker across multiple laboratories, studies need to be performed to understand the relationship between the different platforms.
We have analyzed CSF samples from both diseased and nondiseased subjects with two different widely used assay platforms.
The results showed that different values for the levels of CSF Aβ42 were reported, depending on the assay used.
Nonetheless, both assays clearly demonstrated statistically significant differences in the levels of Aβ42 in CSF from AD relative to age-matched controls (AMC).
This paper provides essential data for establishing the relationship between these assays and provides an important step towards the validation of Aβ42 as a biomarker for AD.
American Psychological Association (APA)
Ellis, Teresa A.& Li, Jinhe& LeBlond, David& Waring, Jeffrey F.. 2012. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-513628
Modern Language Association (MLA)
Ellis, Teresa A.…[et al.]. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-513628
American Medical Association (AMA)
Ellis, Teresa A.& Li, Jinhe& LeBlond, David& Waring, Jeffrey F.. The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-513628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513628