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Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism
المؤلفون المشاركون
Li, Jingyun
Seidel, Lisa
Melnyk, Stepan
Trusty, Timothy A.
Rose, Shannon
Pavliv, Oleksandra
James, S. Jill
Nick, Todd
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The modulation of the redox microenvironment is an important regulator of immune cell activation and proliferation.
To investigate immune cell redox status in autism we quantified the intracellular glutathione redox couple (GSH/GSSG) in resting peripheral blood mononuclear cells (PBMCs), activated monocytes and CD4 T cells and the extracellular cysteine/cystine redox couple in the plasma from 43 children with autism and 41 age-matched control children.
Resting PBMCs and activated monocytes from children with autism exhibited significantly higher oxidized glutathione (GSSG) and percent oxidized glutathione equivalents and decreased glutathione redox status (GSH/GSSG).
In activated CD4 T cells from children with autism, the percent oxidized glutathione equivalents were similarly increased, and GSH and GSH/GSSG were decreased.
In the plasma, both glutathione and cysteine redox ratios were decreased in autistic compared to control children.
Consistent with decreased intracellular and extracellular redox status, generation of free radicals was significantly elevated in lymphocytes from the autistic children.
These data indicate primary immune cells from autistic children have a more oxidized intracellular and extracellular microenvironment and a deficit in glutathione-mediated redox/antioxidant capacity compared to control children.
These results suggest that the loss of glutathione redox homeostasis and chronic oxidative stress may contribute to immune dysregulation in autism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rose, Shannon& Melnyk, Stepan& Trusty, Timothy A.& Pavliv, Oleksandra& Seidel, Lisa& Li, Jingyun…[et al.]. 2011. Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism. Autism Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rose, Shannon…[et al.]. Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism. Autism Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-513815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rose, Shannon& Melnyk, Stepan& Trusty, Timothy A.& Pavliv, Oleksandra& Seidel, Lisa& Li, Jingyun…[et al.]. Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism. Autism Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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