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Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells
المؤلفون المشاركون
Kobayashi, Mizuki
Fujimoto, Naohiro
Matsumoto, Tetsuro
Han, Bin
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor.
Although docetaxel and cabazitaxel can prolong the survival of patients with CRPC, inevitable progression appears following those treatments.
It is urgently required to identify better or alternative therapeutic strategies.
The purpose of this study was to confirm the anti-cancer activity of zoledronic acid (Zol) and determine whether inhibition of geranylgeranylation in the mevalonate pathway could be a molecular target of prostate cancer treatment.
We examined the growth inhibitory effect of Zol in prostate cancer cells (LNCaP, PC3, DU145) and investigated a role of geranylgeranylation in the anticancer activity of Zol.
We, then, evaluated the growth inhibitory effect of geranylgeranyltransferase inhibitor (GGTI), and analyzed the synergy of GGTI and docetaxel by combination index and isobolographic analysis.
Zol inhibited the growth of all prostate cancer cell lines tested in a dose-dependent manner through inhibition of geranylgeranylation.
GGTI also inhibited the prostate cancer cell growth and the growth inhibitory effect was augmented by a combination with docetaxel.
Synergism between GGTI and docetaxel was observed across a broad range of concentrations.
In conclusion, our results demonstrated that GGTI can inhibit the growth of prostate cancer cells and has synergistic effect with docetaxel, suggesting its potential role in prostate cancer treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Bin& Fujimoto, Naohiro& Kobayashi, Mizuki& Matsumoto, Tetsuro. 2011. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Bin…[et al.]. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-513974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Bin& Fujimoto, Naohiro& Kobayashi, Mizuki& Matsumoto, Tetsuro. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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