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Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells
Joint Authors
Kobayashi, Mizuki
Fujimoto, Naohiro
Matsumoto, Tetsuro
Han, Bin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor.
Although docetaxel and cabazitaxel can prolong the survival of patients with CRPC, inevitable progression appears following those treatments.
It is urgently required to identify better or alternative therapeutic strategies.
The purpose of this study was to confirm the anti-cancer activity of zoledronic acid (Zol) and determine whether inhibition of geranylgeranylation in the mevalonate pathway could be a molecular target of prostate cancer treatment.
We examined the growth inhibitory effect of Zol in prostate cancer cells (LNCaP, PC3, DU145) and investigated a role of geranylgeranylation in the anticancer activity of Zol.
We, then, evaluated the growth inhibitory effect of geranylgeranyltransferase inhibitor (GGTI), and analyzed the synergy of GGTI and docetaxel by combination index and isobolographic analysis.
Zol inhibited the growth of all prostate cancer cell lines tested in a dose-dependent manner through inhibition of geranylgeranylation.
GGTI also inhibited the prostate cancer cell growth and the growth inhibitory effect was augmented by a combination with docetaxel.
Synergism between GGTI and docetaxel was observed across a broad range of concentrations.
In conclusion, our results demonstrated that GGTI can inhibit the growth of prostate cancer cells and has synergistic effect with docetaxel, suggesting its potential role in prostate cancer treatment.
American Psychological Association (APA)
Han, Bin& Fujimoto, Naohiro& Kobayashi, Mizuki& Matsumoto, Tetsuro. 2011. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513974
Modern Language Association (MLA)
Han, Bin…[et al.]. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-513974
American Medical Association (AMA)
Han, Bin& Fujimoto, Naohiro& Kobayashi, Mizuki& Matsumoto, Tetsuro. Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. Prostate Cancer. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513974