Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis
المؤلفون المشاركون
Abd al-Mutaal, Fatimah Kamil Muhammad
Fath Allah, Mahmud M.
al-Janzuri, Amal M.
Abd al-Karim, Ula
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 41، العدد 3 (30 سبتمبر/أيلول 2014)، ص ص. 98-102، 5ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2014-09-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background : Interleukin-1 (IL-1) plays an important role in the pathogenesis of osteoarthritis.
Hence, agents that inhibit such cytokine have a high therapeutic potential.
A method of therapy depends on competitive inhibition of IL-1 at the receptor level-that is, IL-1 receptor antagonist ; such antagonist is called Orthokin, which is a normal product of monocytes and is prepared within autologous conditioned serum (ACS) from the patient’s own blood cells.
It is capable of blocking the effects of IL-1, including the induction of matrix metalloproteinases, prostaglandin E2 synthesis, and expression of other cytokines.
Objective : The aim of the study was to clinically evaluate the effect of intra-articular injection of low-dose ACS enriched with Orthokin on primary knee osteoarthritis to assess its validity in treatment.
Patients and methods : This study included 30 knees with primary osteoarthritis.
Baseline clinical evaluation using WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was performed.
Then ACS enriched with Orthokin (IL-1 receptor antagonist) was prepared.
The knee joint was injected with 1 ml ACS weekly for 3 successive weeks.
Patients were assessed using WOMAC questionnaire (1 week after each injection for 3 weeks and monthly after the last injection for 3 months).
Results : On comparing WOMAC score with baseline data, there was a highly significant improvement in all scores, where P was less than 0.01 during all assessment periods and improvement persisted until the end of follow-up after 3 months in comparison with baseline data.
Conclusion : The synthesis and introduction of interleukin-1 receptor antagonists derived from own blood cells established a promising strategy in the treatment of osteoarthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Mutaal, Fatimah Kamil Muhammad& al-Janzuri, Amal M.& Fath Allah, Mahmud M.& Abd al-Karim, Ula. 2014. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 3, pp.98-102.
https://search.emarefa.net/detail/BIM-520230
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Mutaal, Fatimah Kamil Muhammad…[et al.]. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 3 (2014), pp.98-102.
https://search.emarefa.net/detail/BIM-520230
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Mutaal, Fatimah Kamil Muhammad& al-Janzuri, Amal M.& Fath Allah, Mahmud M.& Abd al-Karim, Ula. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 3, pp.98-102.
https://search.emarefa.net/detail/BIM-520230
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 102
رقم السجل
BIM-520230
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر