Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis
Joint Authors
Abd al-Mutaal, Fatimah Kamil Muhammad
Fath Allah, Mahmud M.
al-Janzuri, Amal M.
Abd al-Karim, Ula
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 41, Issue 3 (30 Sep. 2014), pp.98-102, 5 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2014-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background : Interleukin-1 (IL-1) plays an important role in the pathogenesis of osteoarthritis.
Hence, agents that inhibit such cytokine have a high therapeutic potential.
A method of therapy depends on competitive inhibition of IL-1 at the receptor level-that is, IL-1 receptor antagonist ; such antagonist is called Orthokin, which is a normal product of monocytes and is prepared within autologous conditioned serum (ACS) from the patient’s own blood cells.
It is capable of blocking the effects of IL-1, including the induction of matrix metalloproteinases, prostaglandin E2 synthesis, and expression of other cytokines.
Objective : The aim of the study was to clinically evaluate the effect of intra-articular injection of low-dose ACS enriched with Orthokin on primary knee osteoarthritis to assess its validity in treatment.
Patients and methods : This study included 30 knees with primary osteoarthritis.
Baseline clinical evaluation using WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was performed.
Then ACS enriched with Orthokin (IL-1 receptor antagonist) was prepared.
The knee joint was injected with 1 ml ACS weekly for 3 successive weeks.
Patients were assessed using WOMAC questionnaire (1 week after each injection for 3 weeks and monthly after the last injection for 3 months).
Results : On comparing WOMAC score with baseline data, there was a highly significant improvement in all scores, where P was less than 0.01 during all assessment periods and improvement persisted until the end of follow-up after 3 months in comparison with baseline data.
Conclusion : The synthesis and introduction of interleukin-1 receptor antagonists derived from own blood cells established a promising strategy in the treatment of osteoarthritis.
American Psychological Association (APA)
Abd al-Mutaal, Fatimah Kamil Muhammad& al-Janzuri, Amal M.& Fath Allah, Mahmud M.& Abd al-Karim, Ula. 2014. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 3, pp.98-102.
https://search.emarefa.net/detail/BIM-520230
Modern Language Association (MLA)
Abd al-Mutaal, Fatimah Kamil Muhammad…[et al.]. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 3 (2014), pp.98-102.
https://search.emarefa.net/detail/BIM-520230
American Medical Association (AMA)
Abd al-Mutaal, Fatimah Kamil Muhammad& al-Janzuri, Amal M.& Fath Allah, Mahmud M.& Abd al-Karim, Ula. Low-dose intra-articular autologous conditioned serum in treatment of primary knee osteoarthritis. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 3, pp.98-102.
https://search.emarefa.net/detail/BIM-520230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 102
Record ID
BIM-520230