Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney
المؤلف
al-Maghribi, Umar Abd al-Hakim
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 22، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 227-231، 5ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study was aimed to investigate the ability of quercetin (QE) to ameliorate adverse effects of cisplatin (Cis.) on the renal tissue antioxidants by investigating the kidney antioxidant gene expression and the antioxidant enzymes activity.
Forty rats divided into.
Control rats.
QE treated rats were orally administered 100 mg QE/kg for successive 30 days.
Cis.
injected rats were administered i.p.
Cis.
(12 mg / kg b.w.) for 5 mutual days.
Cis.
+ QE rats were administered Cis.
i.p.
(12 mg / kg) and orally administered 100 mg QE / kg for consecutive 30 days.
The obtained results indicated that Cis.
Induced oxidative stress in the renal tissue.
That was through induction of free radical production, inhibition of the activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) as well their genes expression.
At the same time, vitamin E, vitamin C and reduced glutathione (GSH) levels were decreased.
QE had the ability to overcome cisplatin-induced oxidative stress through the reduction of free radical levels.
The antioxidant genes expression and antioxidant enzymes activity were induced.
Finally the vitamin E, vitamin C and GSH levels were increased.
Our work, proved the renoprotective effects of QE against oxidative stress induced by cisplatin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Maghribi, Umar Abd al-Hakim. 2015. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences،Vol. 22, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-527555
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Maghribi, Umar Abd al-Hakim. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences Vol. 22, no. 2 (2015), pp.227-231.
https://search.emarefa.net/detail/BIM-527555
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Maghribi, Umar Abd al-Hakim. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-527555
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 231
رقم السجل
BIM-527555
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر