Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney
Author
al-Maghribi, Umar Abd al-Hakim
Source
Saudi Journal of Biological Sciences
Issue
Vol. 22, Issue 2 (30 Jun. 2015), pp.227-231, 5 p.
Publisher
Publication Date
2015-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The present study was aimed to investigate the ability of quercetin (QE) to ameliorate adverse effects of cisplatin (Cis.) on the renal tissue antioxidants by investigating the kidney antioxidant gene expression and the antioxidant enzymes activity.
Forty rats divided into.
Control rats.
QE treated rats were orally administered 100 mg QE/kg for successive 30 days.
Cis.
injected rats were administered i.p.
Cis.
(12 mg / kg b.w.) for 5 mutual days.
Cis.
+ QE rats were administered Cis.
i.p.
(12 mg / kg) and orally administered 100 mg QE / kg for consecutive 30 days.
The obtained results indicated that Cis.
Induced oxidative stress in the renal tissue.
That was through induction of free radical production, inhibition of the activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) as well their genes expression.
At the same time, vitamin E, vitamin C and reduced glutathione (GSH) levels were decreased.
QE had the ability to overcome cisplatin-induced oxidative stress through the reduction of free radical levels.
The antioxidant genes expression and antioxidant enzymes activity were induced.
Finally the vitamin E, vitamin C and GSH levels were increased.
Our work, proved the renoprotective effects of QE against oxidative stress induced by cisplatin.
American Psychological Association (APA)
al-Maghribi, Umar Abd al-Hakim. 2015. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences،Vol. 22, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-527555
Modern Language Association (MLA)
al-Maghribi, Umar Abd al-Hakim. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences Vol. 22, no. 2 (2015), pp.227-231.
https://search.emarefa.net/detail/BIM-527555
American Medical Association (AMA)
al-Maghribi, Umar Abd al-Hakim. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-527555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 231
Record ID
BIM-527555