Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis
المؤلفون المشاركون
Abd al-Rahim, Daliyah M.
Uthman, Nisrin A. A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 27، العدد 1 (31 مارس/آذار 2015)، ص ص. 1-9، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2015-03-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
A disintegrin and metalloprotease 8 (ADAM8) is a trans-membrane protein, which is involved in cell adhesion, signaling and migration as well as the proteolytic cleavage of various substrates.
Endostatin is a potent inhibitor of angiogenesis.
ADAM8 and Endostatin have been associated with multiple malignancies.
However, their role in osteosarcoma is not fully elucidated.
Aim: To determine the expression of ADAM8 and endostatin in osteosarcoma and to study their correlation with different clinicopathological parameters and patients’ outcomes.
Material and methods: ADAM8 and endostatin expression were immunohistochemically evaluated in 61 primary osteosarcomas and 11 pulmonary metastatic osteosarcoma lesions.
Results: Among 61 primary osteosarcomas, ADAM8 was detected in 52 tumors (85.2%) and highly expressed in 33 cases (54.1%).
Positive endostatin expression was found in 28 tumors (45.9%).
Higher ADAM8 and decreased endostatin expression rates in metastatic lesions compared to primary osteosarcoma were found but these differences were not statistically significant (p= 0.086 & 0.558 respectively).
High ADAM8 expression score and positive endostatin expression were significantly correlated with tumor size, stage and distant metastasis (p< 0.05).
Survival analysis showed that high ADAM8 expression was associated with poor overall survival (OS) (p= 0.0002).
Multivariate analysis revealed that ADAM8 expression level was an independent prognostic parameter for the OS (p= 0.017).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. 2015. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-544526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute Vol. 27, no. 1 (Mar. 2015), pp.1-9.
https://search.emarefa.net/detail/BIM-544526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-544526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-544526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر