Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis
Joint Authors
Abd al-Rahim, Daliyah M.
Uthman, Nisrin A. A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 27, Issue 1 (31 Mar. 2015), pp.1-9, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
A disintegrin and metalloprotease 8 (ADAM8) is a trans-membrane protein, which is involved in cell adhesion, signaling and migration as well as the proteolytic cleavage of various substrates.
Endostatin is a potent inhibitor of angiogenesis.
ADAM8 and Endostatin have been associated with multiple malignancies.
However, their role in osteosarcoma is not fully elucidated.
Aim: To determine the expression of ADAM8 and endostatin in osteosarcoma and to study their correlation with different clinicopathological parameters and patients’ outcomes.
Material and methods: ADAM8 and endostatin expression were immunohistochemically evaluated in 61 primary osteosarcomas and 11 pulmonary metastatic osteosarcoma lesions.
Results: Among 61 primary osteosarcomas, ADAM8 was detected in 52 tumors (85.2%) and highly expressed in 33 cases (54.1%).
Positive endostatin expression was found in 28 tumors (45.9%).
Higher ADAM8 and decreased endostatin expression rates in metastatic lesions compared to primary osteosarcoma were found but these differences were not statistically significant (p= 0.086 & 0.558 respectively).
High ADAM8 expression score and positive endostatin expression were significantly correlated with tumor size, stage and distant metastasis (p< 0.05).
Survival analysis showed that high ADAM8 expression was associated with poor overall survival (OS) (p= 0.0002).
Multivariate analysis revealed that ADAM8 expression level was an independent prognostic parameter for the OS (p= 0.017).
American Psychological Association (APA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. 2015. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-544526
Modern Language Association (MLA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute Vol. 27, no. 1 (Mar. 2015), pp.1-9.
https://search.emarefa.net/detail/BIM-544526
American Medical Association (AMA)
Abd al-Rahim, Daliyah M.& Uthman, Nisrin A. A.. Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma : Implication in tumor progression and prognosis. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-544526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-544526