Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis
المؤلفون المشاركون
Freidouni, Muhammad Jawad
Najati, Husayn
Salimi, Maryam
Amini, Abd Allah
Noruzian, Muhsin
Asgharie, Muhammad Ali
Rezaian, Milad
Bayat, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 3 (31 مارس/آذار 2015)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2015-03-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Osteoporosis is a disease, which causes bone loss and fractures.
Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis.
Objectives : This study took into consideration the importance of cortical bone in the entire bone's mechanical competence.
Hence, the aim of this study was to assess the effects of different protocols of glucocorticoid administration on the biomechanical properties of tibial bone diaphysis in rats compared to control and low-level laser-treated rats.
Materials and Methods : This experimental study was conducted at Shahid Beheshti University of Medical Sciences, Tehran, Iran.
We used systematic random sampling to divide 40 adult male rats into 8 groups with 5 rats in each group.
Groups were as follows : 1) control, 2) dexamethasone (7 mg/week), 3) dexamethasone (0.7 mg/week), 4) methylprednisolone (7 mg/kg/week), 5) methylprednisolone (5 mg/kg twice weekly), 6) dexamethasone (7 mg/kg three times per week), 7) dexamethasone (0.7 mg/kg thrice per week), and 8) low-level laser-treated rats.
The study periods were 4-7 weeks.
At the end of the treatment periods, we examined the mechanical properties of tibial bone diaphysis.
Data were analyzed by statistical analyses.
Results : Glucocorticoid-treated rats showed weight loss and considerable mortality (21%).
The biomechanical properties (maximum force) of glucocorticoid-treated rats in groups 4 (62 ± 2.9), 6 (63 ± 5.1), and 7 (60 ± 5.3) were comparable with the control (46 ± 1.5) and low-level laser-treated (57 ± 3.2) rats.
Conclusions: In contrast to the findings in humans and certain other species, glucocorticoid administration caused anabolic effect on the cortical bone of tibia diaphysis bone in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Freidouni, Muhammad Jawad& Najati, Husayn& Salimi, Maryam& Bayat, Muhammad& Amini, Abd Allah& Noruzian, Muhsin…[et al.]. 2015. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal،Vol. 17, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-554122
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Freidouni, Muhammad Jawad…[et al.]. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal Vol. 17, no. 3 (Mar. 2015), pp.1-7.
https://search.emarefa.net/detail/BIM-554122
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Freidouni, Muhammad Jawad& Najati, Husayn& Salimi, Maryam& Bayat, Muhammad& Amini, Abd Allah& Noruzian, Muhsin…[et al.]. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-554122
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-554122
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر