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Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis
Joint Authors
Freidouni, Muhammad Jawad
Najati, Husayn
Salimi, Maryam
Amini, Abd Allah
Noruzian, Muhsin
Asgharie, Muhammad Ali
Rezaian, Milad
Bayat, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 3 (31 Mar. 2015), pp.1-7, 7 p.
Publisher
Publication Date
2015-03-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Abstract EN
Osteoporosis is a disease, which causes bone loss and fractures.
Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis.
Objectives : This study took into consideration the importance of cortical bone in the entire bone's mechanical competence.
Hence, the aim of this study was to assess the effects of different protocols of glucocorticoid administration on the biomechanical properties of tibial bone diaphysis in rats compared to control and low-level laser-treated rats.
Materials and Methods : This experimental study was conducted at Shahid Beheshti University of Medical Sciences, Tehran, Iran.
We used systematic random sampling to divide 40 adult male rats into 8 groups with 5 rats in each group.
Groups were as follows : 1) control, 2) dexamethasone (7 mg/week), 3) dexamethasone (0.7 mg/week), 4) methylprednisolone (7 mg/kg/week), 5) methylprednisolone (5 mg/kg twice weekly), 6) dexamethasone (7 mg/kg three times per week), 7) dexamethasone (0.7 mg/kg thrice per week), and 8) low-level laser-treated rats.
The study periods were 4-7 weeks.
At the end of the treatment periods, we examined the mechanical properties of tibial bone diaphysis.
Data were analyzed by statistical analyses.
Results : Glucocorticoid-treated rats showed weight loss and considerable mortality (21%).
The biomechanical properties (maximum force) of glucocorticoid-treated rats in groups 4 (62 ± 2.9), 6 (63 ± 5.1), and 7 (60 ± 5.3) were comparable with the control (46 ± 1.5) and low-level laser-treated (57 ± 3.2) rats.
Conclusions: In contrast to the findings in humans and certain other species, glucocorticoid administration caused anabolic effect on the cortical bone of tibia diaphysis bone in rats.
American Psychological Association (APA)
Freidouni, Muhammad Jawad& Najati, Husayn& Salimi, Maryam& Bayat, Muhammad& Amini, Abd Allah& Noruzian, Muhsin…[et al.]. 2015. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal،Vol. 17, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-554122
Modern Language Association (MLA)
Freidouni, Muhammad Jawad…[et al.]. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal Vol. 17, no. 3 (Mar. 2015), pp.1-7.
https://search.emarefa.net/detail/BIM-554122
American Medical Association (AMA)
Freidouni, Muhammad Jawad& Najati, Husayn& Salimi, Maryam& Bayat, Muhammad& Amini, Abd Allah& Noruzian, Muhsin…[et al.]. Evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 3, pp.1-7.
https://search.emarefa.net/detail/BIM-554122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-554122