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Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia
المؤلفون المشاركون
Majd, Zahrah
al-Ajami, Ghulam Husayn
Matin, Sarah
Namazi, Hamid
Haghpanah, Suzan
Bardestani, Mardih
Karimi, Mahran
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 17، العدد 4 (30 إبريل/نيسان 2015)، ص ص. 1-4، 4ص.
الناشر
تاريخ النشر
2015-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Iron-loaded cardiac complication is the essential cause of mortality in patients with thalassemia.
Early detection and treatment of cardiac over-load can reduce mortality.
Objectives: The current study aimed to evaluate the relationship between serum ferritin levels and T2* magnetic resonance imaging (MRI) of heart and liver and liver iron concentration (LIC) to diagnose iron over load in countries with limited access.
Patients and Methods: In the current cross-sectional study, 85 Iranian patients with thalassemia with the mean age of 22.7 ± 7 years were randomly selected.
All patients were on regular blood transfusion.
Echocardiography of heart and liver T2* MRI, determination of serum ferritin levels, and LIC were performed in all subjects at the same time.
The correlation of serum ferritin levels with T2*MRI of heart and liver, and LIC was assessed.
P value < 0.05 was considered statistically significant.
Results: Abnormal myocardial iron load (T2* MRI < 20 ms) was detected in 58% of the patients and among whom, 36% had severe myocardial iron load (T2* MRI < 10 ms).
Median and interquartile range of serum ferritin levels were 1434 and 2702 respectively in patients with thalassemia.
Serum ferritin levels showed a statistically significant positive correlation with LIC (rs = 0.718, P < 0.001) and significant negative correlation with T2* Heart (rs = -0.329, P = 0.002), and T2* Liver (rs = -0.698, P < 0.001).
However, Ejection fraction was not significantly correlated with serum ferritin levels in the patients (P = 0.399).
Conclusions: Serum ferritin levels can be used to diagnose iron over-load in patients with thalassemiaas an alternative method in areas where T2* MRI is not available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Majd, Zahrah& Haghpanah, Suzan& al-Ajami, Ghulam Husayn& Matin, Sarah& Bardestani, Mardih& Namazi, Hamid…[et al.]. 2015. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal،Vol. 17, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-564886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Majd, Zahrah…[et al.]. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal Vol. 17, no. 4 (Apr. 2015), pp.1-4.
https://search.emarefa.net/detail/BIM-564886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Majd, Zahrah& Haghpanah, Suzan& al-Ajami, Ghulam Husayn& Matin, Sarah& Bardestani, Mardih& Namazi, Hamid…[et al.]. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-564886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4
رقم السجل
BIM-564886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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