Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia

Joint Authors

Majd, Zahrah
al-Ajami, Ghulam Husayn
Matin, Sarah
Namazi, Hamid
Haghpanah, Suzan
Bardestani, Mardih
Karimi, Mahran

Source

Iranian Red Crescent Medical Journal

Issue

Vol. 17, Issue 4 (30 Apr. 2015), pp.1-4, 4 p.

Publisher

Iranian Hospital

Publication Date

2015-04-30

Country of Publication

United Arab Emirates

No. of Pages

4

Main Subjects

Medicine

Topics

Abstract EN

Background: Iron-loaded cardiac complication is the essential cause of mortality in patients with thalassemia.

Early detection and treatment of cardiac over-load can reduce mortality.

Objectives: The current study aimed to evaluate the relationship between serum ferritin levels and T2* magnetic resonance imaging (MRI) of heart and liver and liver iron concentration (LIC) to diagnose iron over load in countries with limited access.

Patients and Methods: In the current cross-sectional study, 85 Iranian patients with thalassemia with the mean age of 22.7 ± 7 years were randomly selected.

All patients were on regular blood transfusion.

Echocardiography of heart and liver T2* MRI, determination of serum ferritin levels, and LIC were performed in all subjects at the same time.

The correlation of serum ferritin levels with T2*MRI of heart and liver, and LIC was assessed.

P value < 0.05 was considered statistically significant.

Results: Abnormal myocardial iron load (T2* MRI < 20 ms) was detected in 58% of the patients and among whom, 36% had severe myocardial iron load (T2* MRI < 10 ms).

Median and interquartile range of serum ferritin levels were 1434 and 2702 respectively in patients with thalassemia.

Serum ferritin levels showed a statistically significant positive correlation with LIC (rs = 0.718, P < 0.001) and significant negative correlation with T2* Heart (rs = -0.329, P = 0.002), and T2* Liver (rs = -0.698, P < 0.001).

However, Ejection fraction was not significantly correlated with serum ferritin levels in the patients (P = 0.399).

Conclusions: Serum ferritin levels can be used to diagnose iron over-load in patients with thalassemiaas an alternative method in areas where T2* MRI is not available.

American Psychological Association (APA)

Majd, Zahrah& Haghpanah, Suzan& al-Ajami, Ghulam Husayn& Matin, Sarah& Bardestani, Mardih& Namazi, Hamid…[et al.]. 2015. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal،Vol. 17, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-564886

Modern Language Association (MLA)

Majd, Zahrah…[et al.]. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal Vol. 17, no. 4 (Apr. 2015), pp.1-4.
https://search.emarefa.net/detail/BIM-564886

American Medical Association (AMA)

Majd, Zahrah& Haghpanah, Suzan& al-Ajami, Ghulam Husayn& Matin, Sarah& Bardestani, Mardih& Namazi, Hamid…[et al.]. Serum ferritin levels correlation with heart and liver mri and lic in patients with transfusion-dependent thalassemia. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 4, pp.1-4.
https://search.emarefa.net/detail/BIM-564886

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 4

Record ID

BIM-564886