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Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children
المؤلفون المشاركون
Ghubriyal, Imad E.
al-Hamshari, Azzah A.
Muhammad, Ashraf G.
Abd al-Rahim, Yumna A.
Talat, Ahmad A.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 26، العدد 3 (31 مايو/أيار 2015)، ص ص. 507-515، 9ص.
الناشر
تاريخ النشر
2015-05-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
- الأطفال
- الجهاز البولي
- التشخيص الطبي
- التشخيص
- السيتوكينات
- وحيدات النوى
- الذئبة الحمامية
- الواسمات الحيوية
- التهاب الكلى الذئبي
الملخص EN
Systemic lupus erythematosus (SLE) is a life-long, life-limiting and multi-systemic autoimmune disease.
Glomerulonephritis is one of the most serious manifestations of SLE.
Younger children have an increased incidence, severity and morbidity of lupus nephritis (LN) compared with adult-onset disease.
Monocyte chemoattractant protein-1 (MCP-1) enhances leukocyte adhesiveness and endothelial permeability in the kidneys of murine and human LN models.
Our study aimed to assess the role of urinary MCP-1 in the early diagnosis of LN activity.
Sixty children, of whom 45 children aged from six to 12 years old and of both sexes (15 SLE patients without nephritis, 15 active LN and 15 inactive LN) fulfilling the American College of Rheumatology Classification Criteria for SLE were studied in comparison with 15 healthy subjects.
We investigated the serum and urinary MCP-1 in all groups using the enzyme-linked immunosorbent assay test.
Urinary MCP-1 was significantly higher in active LN in comparison with inactive LN and controls, and also significantly higher in inactive LN in comparison with SLE without nephritis and controls.
There was also a significant difference between SLE without nephritis and controls.
Serum MCP-1 was significantly higher in the group with active LN in comparison with the inactive group and SLE without nephritis and controls, but there was no significant difference between SLE and controls.
The urinary MCP-1 level correlated well with SLE disease activity as measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance.
We concluded that measurement of MCP-1 in urine may be useful for monitoring the severity of renal involvement in SLE.
We recommend measuring urinary MCP-1 in pediatric SLE for the early diagnosis of LN and for the evaluation of the severity of renal involvement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghubriyal, Imad E.& al-Hamshari, Azzah A.& Muhammad, Ashraf G.& Abd al-Rahim, Yumna A.& Talat, Ahmad A.. 2015. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 3, pp.507-515.
https://search.emarefa.net/detail/BIM-567265
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghubriyal, Imad E.…[et al.]. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 3 (May. 2015), pp.507-515.
https://search.emarefa.net/detail/BIM-567265
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghubriyal, Imad E.& al-Hamshari, Azzah A.& Muhammad, Ashraf G.& Abd al-Rahim, Yumna A.& Talat, Ahmad A.. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 3, pp.507-515.
https://search.emarefa.net/detail/BIM-567265
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 514-515
رقم السجل
BIM-567265
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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