Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children
Joint Authors
Ghubriyal, Imad E.
al-Hamshari, Azzah A.
Muhammad, Ashraf G.
Abd al-Rahim, Yumna A.
Talat, Ahmad A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 3 (31 May. 2015), pp.507-515, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-05-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
- Children
- Urinary system
- Medical diagnosis
- Diagnosis
- Cytokines
- Monocytes
- Lupus erythematosus
- Biomarkers
- Lupus nephritis
Abstract EN
Systemic lupus erythematosus (SLE) is a life-long, life-limiting and multi-systemic autoimmune disease.
Glomerulonephritis is one of the most serious manifestations of SLE.
Younger children have an increased incidence, severity and morbidity of lupus nephritis (LN) compared with adult-onset disease.
Monocyte chemoattractant protein-1 (MCP-1) enhances leukocyte adhesiveness and endothelial permeability in the kidneys of murine and human LN models.
Our study aimed to assess the role of urinary MCP-1 in the early diagnosis of LN activity.
Sixty children, of whom 45 children aged from six to 12 years old and of both sexes (15 SLE patients without nephritis, 15 active LN and 15 inactive LN) fulfilling the American College of Rheumatology Classification Criteria for SLE were studied in comparison with 15 healthy subjects.
We investigated the serum and urinary MCP-1 in all groups using the enzyme-linked immunosorbent assay test.
Urinary MCP-1 was significantly higher in active LN in comparison with inactive LN and controls, and also significantly higher in inactive LN in comparison with SLE without nephritis and controls.
There was also a significant difference between SLE without nephritis and controls.
Serum MCP-1 was significantly higher in the group with active LN in comparison with the inactive group and SLE without nephritis and controls, but there was no significant difference between SLE and controls.
The urinary MCP-1 level correlated well with SLE disease activity as measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance.
We concluded that measurement of MCP-1 in urine may be useful for monitoring the severity of renal involvement in SLE.
We recommend measuring urinary MCP-1 in pediatric SLE for the early diagnosis of LN and for the evaluation of the severity of renal involvement.
American Psychological Association (APA)
Ghubriyal, Imad E.& al-Hamshari, Azzah A.& Muhammad, Ashraf G.& Abd al-Rahim, Yumna A.& Talat, Ahmad A.. 2015. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 3, pp.507-515.
https://search.emarefa.net/detail/BIM-567265
Modern Language Association (MLA)
Ghubriyal, Imad E.…[et al.]. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 3 (May. 2015), pp.507-515.
https://search.emarefa.net/detail/BIM-567265
American Medical Association (AMA)
Ghubriyal, Imad E.& al-Hamshari, Azzah A.& Muhammad, Ashraf G.& Abd al-Rahim, Yumna A.& Talat, Ahmad A.. Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis activity in children. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 3, pp.507-515.
https://search.emarefa.net/detail/BIM-567265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 514-515
Record ID
BIM-567265