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Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids
المؤلفون المشاركون
Rajab, Siham M.
Abd al-Hulwah, Muhammad
Khalaf, Abd al-Fattah A.
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 63، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 39-45، 7ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Corticosteroids are the universally accepted first line therapy for moderate and severe immune thrombocytopenia (ITP).
Objectives: We investigated the effect of a short course prednisolone on serum cystatin C and the appearance of microalbuminuria as markers for renal injury in a group of ITP children.
Methods: The study involved 33 (19 males, 14 females) newly diagnosed ITP children divided into two groups; group I included 15 children with no or mild bleeding treated according to ‘‘watch and wait’’ policy; group II included 18 children of moderate or severe bleeding treated by oral prednisolone.
Fifteen healthy, age and sex matched children were enrolled as a control group.
Blood urea, serum creatinine, estimated glomerular filtration rate (eGFR) by Schwartz formula, serum cystatin C (by ELISA) and urinary albumin concentration (by immunoturbidimetric assay) were determined.
Results: The baseline investigations were comparable in the three groups and were within the reference ranges.
Corticosteroids of 12 mg/kg cumulative dose had induced significant increments in serum creatinine [from 0.62 ± 0.16 to 0.84 ±0.12 mg/dL, p< 0.0001] cystatin C [from 750.83± 108.1 to 2300.55 ± 991.94 ng/ml, p< 0.0001] and decreased eGFR [from 116.69± 40.87 to 79.76 ± 24.48 ml/min/1.73 m2, p= 0.001] without change in urinary albumin concentration or induction of microalbuminuria in paired analysis.
Conclusion: Although not accompanied by microalbuminuria, steroid induced cystatin C elevation could be attributed in part to impaired GFR.
Large population follow up studies are recommended to investigate the reversibility of this effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rajab, Siham M.& Abd al-Hulwah, Muhammad& Khalaf, Abd al-Fattah A.. 2015. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette،Vol. 63, no. 2, pp.39-45.
https://search.emarefa.net/detail/BIM-591997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rajab, Siham M.…[et al.]. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette Vol. 63, no. 2 (Jun. 2015), pp.39-45.
https://search.emarefa.net/detail/BIM-591997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rajab, Siham M.& Abd al-Hulwah, Muhammad& Khalaf, Abd al-Fattah A.. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette. 2015. Vol. 63, no. 2, pp.39-45.
https://search.emarefa.net/detail/BIM-591997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 44-45
رقم السجل
BIM-591997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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