Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids
Joint Authors
Rajab, Siham M.
Abd al-Hulwah, Muhammad
Khalaf, Abd al-Fattah A.
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 63, Issue 2 (30 Jun. 2015), pp.39-45, 7 p.
Publisher
Egyptian Pediatric Association
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Corticosteroids are the universally accepted first line therapy for moderate and severe immune thrombocytopenia (ITP).
Objectives: We investigated the effect of a short course prednisolone on serum cystatin C and the appearance of microalbuminuria as markers for renal injury in a group of ITP children.
Methods: The study involved 33 (19 males, 14 females) newly diagnosed ITP children divided into two groups; group I included 15 children with no or mild bleeding treated according to ‘‘watch and wait’’ policy; group II included 18 children of moderate or severe bleeding treated by oral prednisolone.
Fifteen healthy, age and sex matched children were enrolled as a control group.
Blood urea, serum creatinine, estimated glomerular filtration rate (eGFR) by Schwartz formula, serum cystatin C (by ELISA) and urinary albumin concentration (by immunoturbidimetric assay) were determined.
Results: The baseline investigations were comparable in the three groups and were within the reference ranges.
Corticosteroids of 12 mg/kg cumulative dose had induced significant increments in serum creatinine [from 0.62 ± 0.16 to 0.84 ±0.12 mg/dL, p< 0.0001] cystatin C [from 750.83± 108.1 to 2300.55 ± 991.94 ng/ml, p< 0.0001] and decreased eGFR [from 116.69± 40.87 to 79.76 ± 24.48 ml/min/1.73 m2, p= 0.001] without change in urinary albumin concentration or induction of microalbuminuria in paired analysis.
Conclusion: Although not accompanied by microalbuminuria, steroid induced cystatin C elevation could be attributed in part to impaired GFR.
Large population follow up studies are recommended to investigate the reversibility of this effect.
American Psychological Association (APA)
Rajab, Siham M.& Abd al-Hulwah, Muhammad& Khalaf, Abd al-Fattah A.. 2015. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette،Vol. 63, no. 2, pp.39-45.
https://search.emarefa.net/detail/BIM-591997
Modern Language Association (MLA)
Rajab, Siham M.…[et al.]. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette Vol. 63, no. 2 (Jun. 2015), pp.39-45.
https://search.emarefa.net/detail/BIM-591997
American Medical Association (AMA)
Rajab, Siham M.& Abd al-Hulwah, Muhammad& Khalaf, Abd al-Fattah A.. Serum cystatin C and microalbuminuria in children with immune thrombocytopenia under short course of corticosteroids. Egyptian Pediatric Association Gazette. 2015. Vol. 63, no. 2, pp.39-45.
https://search.emarefa.net/detail/BIM-591997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 44-45
Record ID
BIM-591997