Turbidimetric determination of metoclopramide hydrochloride in pharmaceutical preparation via the use of a new homemade Ayah 6SX1-T-2D Solar cell-continuous flow injection analyser

الملخص EN

A newly developed analytical method characterized by its speed and sensitivity for the determination of metoclopramide hydrochloride (MCP-HCl) in pure and pharmaceutical preparation via turbidimetric measurement (0-180o) by Ayah 6SX1-T-2D Solar cell-CFI Analyser.

The method was based on the reaction of phosphomolybdic acid with metoclopramide hydrochloride in acidic medium to form yellowish white precipitate for the ion-pair complex.

Turbidity was measured via the reflection of incident light that collides on the surface precipitated particles at 0-180o.

Chemical and physical parameters were studied and optimized.

The calibration graph was linear in the range of 0.0005-3 or 0.0005- 4 mMol.L-1, with correlation coefficient r = 0.9947&0.9845 respectively.

The limit of detection 3.543 ng/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD % lower than 0.3 % for 1, 3 mMol.L-1 (n = 8) concentration of metoclopramide hydrochloride .

The method was successfully applied to the determination of metoclopramide hydrochloride in three pharmaceutical drugs.

A comparison was made between the newly developed method analysis with the classical method (HANNA instrument for turbidity measurement) using the standard addition method via the use of t-test.

It was noticed that there was no significant difference between two methods at 95 % confidence level.